The Hallmarks of Cancer are one of the most widely recognized organizing principles for the holistic study of cancer. Its profoundly simple framework was first introduced in 2000 b...
PanCancer IO 360™ Panel
Facilitating rapid discovery and development of potentially predictive signatures with the most advanced view of immuno-oncology biology.
The PanCancer IO 360 Gene Expression Panel is a unique 770 gene expression panel for research use only (RUO) that combines vital components involved in the complex interplay between the tumor, microenvironment and immune response in cancer allowing for a multifaceted characterization of disease biology and interrogation of mechanisms of immune evasion.
Developed specifically for translational research, this powerful new panel incorporates 15+ potentially predictive Research Use Only (RUO) biological signatures including the 18-gene Tumor Inflammation Signature as recently described in JCI.1
- Translational RUO panel for the research of possible predictive signatures for potential immunotherapy companion diagnostics
- Allows for possible identification of responder/non-responder populations for immunotherapy research
- Characterize disease biology
- Interrogate mechanisms of immune evasion
Tumor-Microenvironment-Immune Response
| Tumor Foreignness | Tumor Fitness | Tumor Immune Evasion | Immune Access to Tumor | Inhibitory Metabolism | Cytolytic Immune Activity | Suppressive Immunity | Immune Cell Population Abundance | |
|---|---|---|---|---|---|---|---|---|
| Antigen processing machinery | Apoptosis | PDL1 gene expression | Stroma abundance | Glycolytic activity | Tumor Inflammation Signature | Myeloid-derived Inflammatory signaling | B-cells | Mast Cells |
| Proteasome | Proliferation - Tumor proliferation | IDO1 gene expression | Endothelial cells | Hypoxia | Cytotoxicity | Inflammatory chemokines | CD45 | Neutrophils |
| MAGE family gene expression | Loss of JAK-STAT pathway gene expression | Interferon gamma | ARG1 gene expression | CD8 T cells | NK CD56dim cells | |||
| Loss of antigen processing and presentation gene expression | Interferon downstream signaling | NOS2 gene expression | Cytotoxic cells | NK cells | ||||
| Loss of mismatch repair gene expression | Lymphoid compartment activity | CTLA4 gene expression | DC | T-cells | ||||
| Myeloid compartment activity | IL10 gene expression | Exhausted CD8 | Th1 cells (T-bet expression) | |||||
| HLA class 2 antigen presentation | PDL2 gene expression | Macrophages | Treg (FOXP3 expression) |
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